Basic Information
VIS ID
TVIS44000621
Fusion event
HTLV-1-FBXO33 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
39875571/39406367 (Hg38)
End
39875571/39406367 (Hg38)
Orient
+
Location type
Intronic
Target gene
FBXO33
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-181a-5p ; hsa-mir-505-3p ; hsa-mir-1199-5p ; hsa-mir-3136-5p ; hsa-mir-3177-5p ; hsa-mir-4439 ; hsa-mir-449b-3p ; hsa-mir-4513 ; hsa-mir-6751-3p ; hsa-mir-6807-5p ; hsa-mir-6855-3p ; hsa-mir-6857-3p
Nearest miRNA
hsa-mir-208a/Upstream/2453976; hsa-mir-1185-1/Downstream/8354628;
Nearest TSS
ENST00000550708/Upstream/58822; ENST00000556620/Downstream/25508;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/138669, chr14-CpG: 127/Downstream/25105
Upstream sequence
AATTTCTAATAATACTCAGAGGGGACAGTCATACAGTCTCAGTATTTTTCTCCTTTCAACTCAACTTTCATTTATTTGGTGGTAttaaaatacacatgta
Downstream sequence
agagacttttacttcttctacaaagaaacactaaggacaacggccttccctctgtaaacaactataaaactagagaaaacaaaataattgttttcagaca
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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