Basic Information
VIS ID
TVIS44000622
Fusion event
HTLV-1-MDGA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
47826640/47357437 (Hg38)
End
47826640/47357437 (Hg38)
Orient
+
Location type
Intronic
Target gene
MDGA2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-335-3p ; hsa-mir-3180-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-153-5p ; hsa-mir-1250-3p
Nearest miRNA
hsa-mir-208a/Upstream/10405046; hsa-mir-1185-1/Downstream/403558;
Nearest TSS
ENST00000550708/Upstream/14203; ENST00000557531/Downstream/269088;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/705481, chr14-CpG: 186/Downstream/316793
Upstream sequence
tttcaccctatcatccaacactttggcagctaacacagggaggctctcgaaaatgtgcatatttctccaaattcactagacagtgtagggttggacaatc
Downstream sequence
aattggccttagactatttactagcagaacagggaggggtatatgcagtcaccagtaccttctgttgcacctgggtaagcacctctgggaaaacagaggt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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