Basic Information
VIS ID
TVIS44000625
Fusion event
HTLV-1-DMXL2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
51806707/51514510 (Hg38)
End
51806707/51514510 (Hg38)
Orient
+
Location type
Exonic
Target gene
DMXL2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-205-5p
Nearest miRNA
hsa-mir-10393/Upstream/200401; hsa-mir-11181/Downstream/762607;
Nearest TSS
ENST00000557528/Upstream/33031; ENST00000558709/Downstream/89191;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/172389, chr15-CpG: 109/Downstream/107460
Upstream sequence
TAAACAAATGCAGACTATTTTTTTAAAGTACCTTGTGATGGCTGAAAAAATATTTCTGTTTCCTTTTTCTCCATATCTTCCTTATGTGGTTTATATCCTA
Downstream sequence
TAATGAAGTCTTCTTGAAACACATGAAGCAACTGTGTATTTGAGCCACACTACAAATACAAAAAAAAATGAAGAGGTTTTATCTTTGAAATTCCCTGTCT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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