Basic Information
VIS ID
TVIS44000628
Fusion event
HTLV-1-LRRC28 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
99809967/99269762 (Hg38)
End
99809967/99269762 (Hg38)
Orient
+
Location type
Intronic
Target gene
LRRC28
miRNAs that regulate target gene
hsa-mir-34a-5p
Nearest miRNA
hsa-mir-10393/Upstream/485260; hsa-mir-1302-10/Downstream/2690697;
Nearest TSS
ENST00000557528/Upstream/17951; ENST00000558771/Downstream/16940;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/17925, chr15-CpG: 154/Downstream/295401
Upstream sequence
aaagtgttaggattacaggtgtgagctaccatgcctggccttaacatttaaattaaagtaaaataatattaaaaattcagttcctccatcacatagccac
Downstream sequence
attttaagtgcttcatagccacatgtggctagtgtctgccatattggacaacacagataatgtttccatcatggcagagagAGAAACAAAGGAAAATGAG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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