Basic Information
VIS ID
TVIS44000633
Fusion event
HTLV-1-NETO2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
47150684/47116773 (Hg38)
End
47150684/47116773 (Hg38)
Orient
+
Location type
Intronic
Target gene
NETO2
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-375 ; hsa-mir-24-3p ; hsa-mir-21-5p ; hsa-mir-20a-5p ; hsa-mir-4480 ; hsa-mir-599 ; hsa-mir-3161 ; hsa-mir-526b-5p ; hsa-mir-3190-3p ; hsa-mir-143-5p ; hsa-mir-382-5p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-4796-3p ; hsa-mir-106b-5p ; hsa-mir-519d-3p ; hsa-mir-17-5p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-526b-3p ; hsa-mir-106a-5p ; hsa-mir-1229-3p ; hsa-mir-7160-3p ; hsa-mir-342-3p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-3924 ; hsa-mir-203a-3p ; hsa-mir-380-3p ; hsa-mir-411-3p ; hsa-mir-379-3p ; hsa-mir-4495 ; hsa-mir-522-3p ; hsa-mir-224-3p ; hsa-mir-3646 ; hsa-mir-3662 ; hsa-mir-424-3p ; hsa-mir-548ad-3p ; hsa-mir-4284 ; hsa-mir-4755-3p ; hsa-mir-4493 ; hsa-mir-4753-5p
Nearest miRNA
hsa-mir-1225/Upstream/12953100; hsa-mir-11401/Downstream/3175843;
Nearest TSS
ENST00000527434/Upstream/7139; ENST00000565694/Downstream/6130;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/78514, chr16-CpG: 48/Downstream/344013
Upstream sequence
gatactaaagaattggcattatatcttccttgaatgtttggtacaatttgccagcgaacccatctaggcctagagttttctttgttagaaggtgtttacg
Downstream sequence
aattcattttttgaataagcacaggatgatttgggttgtgtatgtctactgggacatgtttgggcagctgtgtagcttttaagagatttacccatttcat
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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