Basic Information
VIS ID
TVIS44000645
Fusion event
HTLV-1-LOXHD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
44175825/46595862 (Hg38)
End
44175825/46595862 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOXHD1
miRNAs that regulate target gene
hsa-mir-25-3p
Nearest miRNA
hsa-mir-1-2/Upstream/1625696; hsa-mir-122/Downstream/784634;
Nearest TSS
ENST00000575820/Upstream/36550; ENST00000585383/Downstream/5801;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/35250, chr18-CpG: 17/Downstream/61014
Upstream sequence
AGGGTATAATCACCAACAATTTATTTACAAGTCTTTCTTTCCTCTCAACAAATCCTGCAGATGTTTCCTCGTTTACTCTTGAATTGTTCTCTCATTGTTA
Downstream sequence
ACTGTGTATTGGTTAGTTTTGTTTTTTTAAGAAGTAGTAAAATCCTAAAAGTCTGAGGTTGTGTGTTTTCTCACCCCATGGGTTCCCTGAACATGGTTCT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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