Basic Information
VIS ID
TVIS44000657
Fusion event
HTLV-1-PARD3B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
206169607/205304883 (Hg38)
End
206169607/205304883 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2I
Target gene
PARD3B
miRNAs that regulate target gene
hsa-mir-6873-3p ; hsa-mir-3941 ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6758-3p ; hsa-mir-4789-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-3180-5p ; hsa-mir-4642 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-891a-3p ; hsa-mir-3688-5p ; hsa-mir-4267
Nearest miRNA
hsa-mir-10b/Upstream/16171772; hsa-mir-1244-1/Downstream/1478351;
Nearest TSS
ENST00000437798/Upstream/11391; ENST00000494482/Downstream/42926;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/758696, chr2-CpG: 91/Downstream/376996
Upstream sequence
aaaaaacacaaattagctgggcatggtggcatgtgcctatagtcccagctactcaggaggctgaagtgggaggattgacttagcctgggaggtagaggat
Downstream sequence
acagtgagccatgatcccttcactggactccagcctgggcaacagagtaagaccctatctcaaaaaattaaaattaaaaagaacaaaatttcagcaaatt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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