Basic Information
VIS ID
TVIS44000663
Fusion event
HTLV-1-CDK5RAP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
31948116/33360310 (Hg38)
End
31948116/33360310 (Hg38)
Orient
+
Location type
Intronic
Target gene
CDK5RAP1
miRNAs that regulate target gene
hsa-mir-16-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/1122463; hsa-mir-1-1/Downstream/688809;
Nearest TSS
ENST00000382410/Upstream/61597; ENST00000471007/Downstream/13049;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/539992, chr20-CpG: 30/Downstream/41028
Upstream sequence
AAGTGCCCTTCCATTGTACTGGTTGAGAGGGGATTTTTATTTTACTAAAATGTGTCTCTAGGAAAAAACTTTATTACCACAAATATCCAAACCAACACTC
Downstream sequence
ATTTCACAGTGCAAGCCAAAAGCCCAAAAGGACTCCTCACCTTCACCAGCACATAGTCCCCAGGCTGGGCTCTGACCCTGAGCCCAGGGTTATTGACATC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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