Basic Information
VIS ID
TVIS44000668
Fusion event
HTLV-1-IRAK2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
10255594/10213910 (Hg38)
End
10255594/10213910 (Hg38)
Orient
+
Location type
Intronic
Target gene
IRAK2
miRNAs that regulate target gene
hsa-mir-146a-5p ; hsa-mir-335-5p ; hsa-mir-1262 ; hsa-mir-1827 ; hsa-mir-1910-3p ; hsa-mir-34b-3p ; hsa-mir-3609 ; hsa-mir-3614-5p ; hsa-mir-3664-3p ; hsa-mir-3664-5p ; hsa-mir-3672 ; hsa-mir-3929 ; hsa-mir-4324 ; hsa-mir-4419b ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4478 ; hsa-mir-4504 ; hsa-mir-4522 ; hsa-mir-4649-3p ; hsa-mir-4695-5p ; hsa-mir-4701-3p ; hsa-mir-4722-5p ; hsa-mir-4768-3p ; hsa-mir-485-5p ; hsa-mir-508-5p ; hsa-mir-510-5p ; hsa-mir-512-5p ; hsa-mir-520g-3p ; hsa-mir-520h ; hsa-mir-548ah-5p ; hsa-mir-6500-3p ; hsa-mir-6510-3p ; hsa-mir-6511a-5p ; hsa-mir-6512-3p ; hsa-mir-661 ; hsa-mir-665 ; hsa-mir-6720-5p ; hsa-mir-6736-5p ; hsa-mir-6742-3p ; hsa-mir-6761-5p ; hsa-mir-6776-5p ; hsa-mir-6808-5p ; hsa-mir-6864-3p ; hsa-mir-6884-5p ; hsa-mir-6893-5p ; hsa-mir-7160-5p ; hsa-mir-766-3p ; hsa-mir-873-3p ; hsa-mir-940
Nearest miRNA
hsa-mir-4790/Upstream/4963655; hsa-let-7g/Downstream/66441;
Nearest TSS
ENST00000440867/Upstream/49045; ENST00000426850/Downstream/34113;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/48570, chr3-CpG: 30/Downstream/20431
Upstream sequence
ttcttctCCTGTGTAGCAATTCTATGTGTAGATTAGAATTATAAAGGAAACTTGGCTTACTCCAACTCCTTCCTTCCACATGGGAATAAATCTTCTCTCC
Downstream sequence
TTTTTTtttttcttttcttttctttttttgttttttgagacagagtcttgctctgtctcccaggctggagtgcagtggcgtgatctcggctcactgcaat
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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