Basic Information
VIS ID
TVIS44000672
Fusion event
HTLV-1-MECOM integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
169073316/169355528 (Hg38)
End
169073316/169355528 (Hg38)
Orient
+
Location type
Intronic
Target gene
MECOM
miRNAs that regulate target gene
hsa-mir-22-3p
Nearest miRNA
hsa-let-7g/Upstream/803579; hsa-mir-1224/Downstream/1067575;
Nearest TSS
ENST00000440867/Upstream/86290; ENST00000480669/Downstream/92339;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/205903, chr3-CpG: 122/Downstream/306121
Nearest cancer related gene
MECOM(OG, No orient, 0)
Upstream sequence
AACTAGGATTGCAAAGTAATCTTCTACCAAACAACTTGTAATTCAAAATTAAATAGATTATAGACAACAGAAGCACTTTGACATGGGGTAAAAAACAACC
Downstream sequence
AATTATTGCACCCAGAGGCTAAAAATAAACTGCCATGTTAAAGTCAAATGTCATCACTGATGTCTTCTTTGGTTTAAAAGATAGCATTATTATCAGTAAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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