VISDB - VIS Detail

Basic Information

VIS ID

TVIS44000677

Fusion event

HTLV-1-OSBPL10 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr3

Cytoband

p23

Reference genome

GRCh37/hg19

Start

31775147/31733655 (Hg38)

End

31775147/31733655 (Hg38)

Orient

Location type

Intronic

Target gene

OSBPL10

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-98-5p ; hsa-let-7b-5p ; hsa-mir-222-3p ; hsa-mir-5698 ; hsa-mir-744-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-513a-5p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-3652 ; hsa-mir-4430 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-6499-3p ; hsa-mir-3135b ; hsa-mir-103b ; hsa-mir-5693 ; hsa-mir-4781-3p ; hsa-mir-143-5p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6736-5p ; hsa-mir-4701-3p ; hsa-mir-1262 ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-7977 ; hsa-mir-6748-5p ; hsa-mir-6769b-5p ; hsa-mir-6769a-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-24-3p ; hsa-mir-3934-3p ; hsa-mir-2467-5p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-383-3p ; hsa-mir-3149 ; hsa-mir-668-3p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-3121-5p ; hsa-mir-483-3p ; hsa-mir-129-5p ; hsa-mir-3152-5p ; hsa-mir-3667-3p ; hsa-mir-4774-3p ; hsa-mir-6734-3p ; hsa-mir-6778-3p ; hsa-mir-6791-3p ; hsa-mir-6829-3p ; hsa-mir-6836-3p

Nearest miRNA

hsa-mir-12127/Upstream/571868; hsa-let-7g/Downstream/772628;

Nearest TSS

ENST00000440867/Upstream/16664; ENST00000489408/Downstream/96419;

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/199865, chr3-CpG: 104/Downstream/246822

Upstream sequence

AAGTGCAGATTCTGATCATCTGTTGATGAACTAGTTTCTGTATAATATCAAGATCAGAATCATCACAGGCTGTTTCACTCCCCAACAGTGGACAAAAACA

Downstream sequence

ATTGCGATTTACCAAAGCCAGATAAAGGTGttttttttttttttttttttttttttGAACTTTTAAAAATATTTCTggccaggtgcggtggctcacgcct

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.