Basic Information
VIS ID
TVIS44000686
Fusion event
HTLV-1-OXCT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
41763317/41763215 (Hg38)
End
41763317/41763215 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
OXCT1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-100-5p
Nearest miRNA
hsa-mir-10397/Upstream/3205654; hsa-mir-103a-1/Downstream/12188289;
Nearest TSS
ENST00000502646/Upstream/23494; ENST00000505931/Downstream/30920;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/252666, chr5-CpG: 104/Downstream/106346
Upstream sequence
CTATAAGGAGATCAAGAAATGCACACAACATGGCTTTAAAACACGGTCTCGAATTCCATGATTTTGGAGACATTTTACAGGTCAATGAAACAGAACATGA
Downstream sequence
ACATGAATTAGATGAGCAGTATGAAGAAAAGAAGTAGTCACCACATTTTTGTGGTTTGGAATCTGTCAGTAAATAAGATAGATGGCAGCTGGCAACAGCT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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