Basic Information
VIS ID
TVIS44000692
Fusion event
HTLV-1-CEP162 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
84872830/84163111 (Hg38)
End
84872830/84163111 (Hg38)
Orient
+
Location type
Intronic
Target gene
CEP162
miRNAs that regulate target gene
hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-513a-5p ; hsa-mir-4320 ; hsa-mir-3134 ; hsa-mir-383-5p ; hsa-mir-1245b-3p ; hsa-mir-1246 ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-6504-3p ; hsa-mir-6856-3p ; hsa-mir-3941 ; hsa-mir-3065-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485
Nearest miRNA
hsa-mir-10398/Upstream/5623802; hsa-mir-1202/Downstream/6149631;
Nearest TSS
ENST00000381078/Upstream/7517; ENST00000591225/Downstream/31919;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/128882, chr6-CpG: 42/Downstream/64287
Upstream sequence
AAAAATGTTTCTAAAATTACAATATACTTCAAGGAGTAGCATTTTGATTATACCATTCAATTTCTATTACTTAAATTCAACATTAGAACAGTTATGATTA
Downstream sequence
TAAAGGTACACTGTTTCAGCTCAGTGTTTTACCTGTGACATAAGCAATCTGATCTTTGGCTTGGTCCCTCTCTTTCTTCATTTTTTCGAAGTCTACTTCA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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