Basic Information
VIS ID
TVIS44000694
Fusion event
HTLV-1-MAP7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
136843366/136522228 (Hg38)
End
136843366/136522228 (Hg38)
Orient
+
Location type
Intronic
Target gene
MAP7
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-93-5p ; hsa-mir-19b-3p ; hsa-mir-16-5p ; hsa-let-7b-5p ; hsa-mir-3613-3p ; hsa-let-7c-3p ; hsa-mir-6866-5p ; hsa-let-7g-3p ; hsa-let-7a-2-3p ; hsa-mir-4766-3p ; hsa-mir-548p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-3646 ; hsa-mir-106a-5p ; hsa-mir-526b-3p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-20a-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-130a-3p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-301b-3p ; hsa-mir-3666 ; hsa-mir-301a-3p ; hsa-mir-493-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-5692a ; hsa-mir-4436b-5p ; hsa-mir-4284 ; hsa-mir-4772-3p ; hsa-mir-4518 ; hsa-mir-1266-5p ; hsa-mir-3664-3p ; hsa-mir-1304-3p ; hsa-mir-6890-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-6741-3p ; hsa-mir-4793-5p ; hsa-mir-205-3p ; hsa-mir-218-1-3p ; hsa-mir-3606-3p ; hsa-mir-513a-3p ; hsa-mir-513c-3p ; hsa-mir-659-3p ; hsa-mir-6758-3p ; hsa-mir-9-5p
Nearest miRNA
hsa-mir-10398/Upstream/1282972; hsa-mir-1202/Downstream/1912985;
Nearest TSS
ENST00000381078/Upstream/55353; ENST00000607749/Downstream/3755;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/161093, chr6-CpG: 160/Downstream/27460
Upstream sequence
AGACCTATCCAAGGGCATTTAGTTACTGCAGCACCTAAACAGTCTCTCCTAAGCCAGTCCTGAAGTCAGCATTACAAGGAGGCTTGAGGTTCCGAGGTAT
Downstream sequence
AAGAGCATCAGCATAAGCCCAGCTCGCTCCCAGTGATTATTTAATTACTGTGGTAATAACAGTCAGGTATGTAAAACATTACACTCCTACCGATTACATG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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