Basic Information
VIS ID
TVIS44000698
Fusion event
HTLV-1-chr6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
45618917/45651180 (Hg38)
End
45618917/45651180 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA6H
Nearest miRNA
hsa-mir-10398/Upstream/453410; hsa-mir-10524/Downstream/6493169;
Nearest TSS
ENST00000381078/Upstream/74410; ENST00000321037/Downstream/286284;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/227271, chr6-CpG: 84/Downstream/12069
Nearby gene
RUNX2(+100098) ;
Nearest cancer related gene
RUNX2(TSG, +100098) ;
Upstream sequence
CAAATGACCAAGGCACCACCCCCACCCCCTTCAATGGACAGGGCCAAATTTAGAGTTGGGGTTGCTCATTTAAGCTTTGTATGTAATTGAGCCTGGCACA
Downstream sequence
AAGGGTTATCATTAGAAGGAATGGCATGAAATGAAGGAATGGAAAAGCTCAGACCCAAATTAGAAAAGATGTCCTGAGGGAGAGACACAGTGGCAAGGCT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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