Basic Information
VIS ID
TVIS44000699
Fusion event
HTLV-1-ARID1B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
157458308/157137174 (Hg38)
End
157458308/157137174 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARID1B
miRNAs that regulate target gene
hsa-mir-92b-3p ; hsa-mir-324-5p ; hsa-mir-92a-3p ; hsa-mir-25-3p ; hsa-mir-32-5p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-578 ; hsa-mir-643 ; hsa-mir-138-2-3p ; hsa-mir-5692a ; hsa-mir-552-5p ; hsa-mir-302c-5p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-mir-3143 ; hsa-let-7a-3p ; hsa-mir-656-3p ; hsa-mir-144-3p ; hsa-mir-602 ; hsa-mir-543
Nearest miRNA
hsa-mir-10398/Upstream/357443; hsa-mir-1913/Downstream/391958;
Nearest TSS
ENST00000381078/Upstream/17468; ENST00000636426/Downstream/11450;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/114916, chr6-CpG: 105/Downstream/98863
Upstream sequence
ggaggctgacatcagaggatcacttgagcccaggaggttgaggctgcagtgagctctgatcacaccactgctctacagcctgggtggcaaagtgagaccc
Downstream sequence
tgtcgcaaaaaataaaataaaataaaatTTCTATGATGTGAAGAAGGGGGAATGTTAGAAATGTATATTAGTACTATAAAATCTGAATTTTTAAATAAAT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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