Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene806223337801705779453574792805967928488279290406792946197929589479298193793172657931829879319695
Basic Information
VIS ID
TVIS44000701
Fusion event
HTLV-1-MAGI2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
78949011/79319695 (Hg38)
End
78949011/79319695 (Hg38)
Orient
+
Location type
Intronic
Target gene
MAGI2
miRNAs that regulate target gene
hsa-mir-655-3p ; hsa-mir-487b-3p ; hsa-mir-134-5p ; hsa-mir-5047 ; hsa-mir-1301-3p ; hsa-mir-3944-5p ; hsa-mir-5690 ; hsa-mir-4660 ; hsa-mir-4704-5p ; hsa-mir-3912-5p ; hsa-mir-487a-3p
Nearest miRNA
hsa-mir-10525/Upstream/3404426; hsa-mir-10399/Downstream/12884320;
Nearest TSS
ENST00000635602/Upstream/179866; ENST00000442586/Downstream/32190;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1278955, chr7-CpG: 26/Downstream/132554
Upstream sequence
tttggaaagcccaagctaagaatgacaaagcagaaaatatgagccatgataacatagttaagtggtcataggaggcctgtacagcctacttatgaattcc
Downstream sequence
ttttctgttagggacaaataaacttctaccatcttaaaactaattttattttgctcttcctgttaaatgaagtcccatctaagcctaactggtacaCACA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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