Basic Information
VIS ID
TVIS44000702
Fusion event
HTLV-1-ZNF777 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
149143560/149446469 (Hg38)
End
149143560/149446469 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
ZNF777
miRNAs that regulate target gene
hsa-mir-296-3p ; hsa-mir-18a-3p ; hsa-mir-106b-5p
Nearest miRNA
hsa-mir-10399/Upstream/2068348; hsa-mir-153-2/Downstream/1791952;
Nearest TSS
ENST00000635602/Upstream/23794; ENST00000486744/Downstream/14654;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/13666, chr7-CpG: 216/Downstream/13001
Upstream sequence
catctcaaaaaaaaaaggaaggatttgggaaggtgggaataaatacatgttcaatctgccctgctcaacTCAATCTTTCATTGTGTACTGTTTTAAAAAA
Downstream sequence
TATATTTTTACTGAATAAGGAGTAATACATGCTCACATCAGAACATTTTAAAAAACATAGAGAAATATGGCTTTGGTATGTTTCCATCCAGTTTTTTTTT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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