Basic Information
VIS ID
TVIS44000707
Fusion event
HTLV-1-KCNB2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
73512867/72600632 (Hg38)
End
73512867/72600632 (Hg38)
Orient
+
Location type
Intronic
Target gene
KCNB2
miRNAs that regulate target gene
hsa-mir-493-3p
Nearest miRNA
hsa-mir-124-1/Upstream/8221375; hsa-mir-10400/Downstream/1947911;
Nearest TSS
ENST00000518652/Upstream/63241; ENST00000564832/Downstream/281108;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/63142, chr8-CpG: 67/Downstream/407991
Upstream sequence
tgtatacatatgtaacaaacctgtacgttgtgtacatgtaccctaaaacttaaagtataataataataaaaTTTAAAAAAAaaagaaaatgtggtatgta
Downstream sequence
tacaccatggaataccatacagccataaaaaaggatgagatcatgtcctttgcgggaacatggatggagctggagactattatccttagcaaactaacag
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate