Basic Information
VIS ID
TVIS44000717
Fusion event
HTLV-1-CASK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p11.4
Reference genome
GRCh37/hg19
Start
41411198/41551945 (Hg38)
End
41411198/41551945 (Hg38)
Orient
+
Location type
Intronic
Target gene
CASK
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-203a-3p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-3908 ; hsa-mir-4724-5p ; hsa-mir-4519 ; hsa-mir-4274 ; hsa-mir-4524b-5p ; hsa-mir-4524a-5p ; hsa-mir-646 ; hsa-mir-503-5p
Nearest miRNA
hsa-mir-1587/Upstream/1714332; hsa-let-7f-2/Downstream/4194212;
Nearest TSS
ENST00000429181/Upstream/17045; ENST00000620846/Downstream/4290;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/77072, chrX-CpG: 143/Downstream/370908
Upstream sequence
ctgcagcctgggccacagggcgagactccgtctcaaaaaaaaaaaaaaaaaaaaaaaaaaTTGGTCACTGAGCTCCCCAGTACCtttttttatttcccgg
Downstream sequence
acacagagtctcactctgtcgtccaggctagagtgcagtggcgcgatcacggctcactgcaacttccacttctcgggctcaagcaattctcctgcctcag
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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