Basic Information
VIS ID
TVIS44000745
Fusion event
HTLV-1-LRRK2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q12
Reference genome
GRCh37/hg19
Start
40736187/40342385 (Hg38)
End
40736187/40342385 (Hg38)
Orient
+
Location type
Intronic
Target gene
LRRK2
miRNAs that regulate target gene
hsa-mir-205-5p ; hsa-mir-335-5p ; hsa-mir-582-3p ; hsa-mir-582-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/14468306; hsa-let-7i/Downstream/1981315;
Nearest TSS
ENST00000382841/Upstream/29671; ENST00000636518/Downstream/4462;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/117274, chr12-CpG: 47/Downstream/350335
Upstream sequence
TGCTGAAAACCTGTCTAAAATGTAATATCCATCTGATTCTTCATACCAAGCCACACAATTCTTCCTGATCCCTTTTAATCTCCAATATTGAATGGTGGTA
Downstream sequence
ACATAAATATGGAGACAGATCATGTCAGAAACCCAGGGCCTAATCTTTTCTTTTCTGCCTACTCTTCTCACAGGCTGCTTAGTACTTTGTAAGCTTTTTT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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