Basic Information
VIS ID
TVIS44000759
Fusion event
HTLV-1-NFATC2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
50147010/51530471 (Hg38)
End
50147010/51530471 (Hg38)
Orient
-
Location type
Intronic
Target gene
NFATC2
miRNAs that regulate target gene
hsa-mir-184 ; hsa-mir-526b-5p ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-451b ; hsa-mir-5571-5p ; hsa-mir-4512 ; hsa-mir-3157-5p ; hsa-mir-20b-3p ; hsa-mir-1304-3p ; hsa-mir-1208 ; hsa-mir-6760-3p ; hsa-mir-1183 ; hsa-mir-10a-3p ; hsa-mir-466 ; hsa-mir-4672 ; hsa-mir-3941 ; hsa-mir-496 ; hsa-mir-6504-3p ; hsa-mir-4700-3p ; hsa-mir-8485 ; hsa-mir-4459 ; hsa-mir-603 ; hsa-mir-129-5p ; hsa-mir-489-3p ; hsa-mir-514a-3p ; hsa-mir-514b-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/77494; hsa-mir-1-1/Downstream/2537937;
Nearest TSS
ENST00000382410/Upstream/131252; ENST00000454600/Downstream/12248;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/6470, chr20-CpG: 71/Downstream/11894
Nearest cancer related gene
NFATC2(TSG, No orient, 0)
Upstream sequence
ttggtcaggctagtctcgaactcctgacctcaagtgatctgcccacctcggcctgccaaagtgctgggattacaggcattagccaccatgcctggccTGA
Downstream sequence
AACTCCACTCCTTCTGACTAGTTCAAAGAGAAAATAGCGCTGAAAAATAGTTCTTAGCACATACAACGTCCTCACTGGTGGACCACCTAAAATCCATTTC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate