Basic Information
VIS ID
TVIS44000762
Fusion event
HTLV-1-ARHGEF3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p14.3
Reference genome
GRCh37/hg19
Start
56899288/56865260 (Hg38)
End
56899288/56865260 (Hg38)
Orient
-
Location type
Intronic
Target gene
ARHGEF3
miRNAs that regulate target gene
hsa-mir-138-5p ; hsa-mir-373-3p ; hsa-mir-335-5p ; hsa-mir-769-5p ; hsa-mir-377-5p ; hsa-mir-485-5p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-889-3p ; hsa-mir-4793-5p ; hsa-mir-5196-3p
Nearest miRNA
hsa-let-7g/Upstream/1012666; hsa-mir-12124/Downstream/3752545;
Nearest TSS
ENST00000440867/Upstream/63293; ENST00000495939/Downstream/51211;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/63078, chr3-CpG: 112/Downstream/213461
Upstream sequence
CTATTTCCACAACCTGACAATAATTTAAATGAAGTCGCAGCCTCAATTTCTGGTTGTATTACAGAGAGGGAACATCATCAAGGCACATAACAAAACTTAA
Downstream sequence
ACAGCAACCTAGAAGAGAACATGCTACCACAGCGCACAGATTGGTTAGAAAGGAGAATGATTCCGCTACGGCAAACAGAGCAGAGCAAAACACAGCAAGT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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