VISDB - VIS Detail

Basic Information

VIS ID

TVIS44000778

Fusion event

HTLV-1-HACD2 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr3

Cytoband

q21.1

Reference genome

GRCh37/hg19

Start

123237349/123518502 (Hg38)

End

123237349/123518502 (Hg38)

Orient

Location type

Intronic

Target gene

HACD2

miRNAs that regulate target gene

hsa-mir-1-3p ; hsa-mir-193b-3p ; hsa-mir-4665-5p ; hsa-mir-1275 ; hsa-mir-5010-5p ; hsa-mir-4525 ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-625-5p ; hsa-mir-6825-5p ; hsa-mir-766-5p ; hsa-mir-3148 ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-6836-5p ; hsa-mir-6132 ; hsa-mir-1205 ; hsa-mir-6894-5p ; hsa-mir-4722-5p ; hsa-mir-1827 ; hsa-mir-3605-5p ; hsa-mir-4649-3p ; hsa-mir-4459 ; hsa-mir-940 ; hsa-mir-6808-5p ; hsa-mir-6893-5p ; hsa-mir-2392 ; hsa-mir-665 ; hsa-mir-6880-5p ; hsa-mir-6799-5p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-7160-5p ; hsa-mir-6134 ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-1247-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-4673 ; hsa-mir-4645-5p ; hsa-mir-4692 ; hsa-mir-4514 ; hsa-mir-6501-3p ; hsa-mir-4762-5p ; hsa-mir-205-3p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-1285-3p ; hsa-mir-196a-3p ; hsa-mir-3187-5p ; hsa-mir-335-5p ; hsa-mir-340-3p ; hsa-mir-4668-5p ; hsa-mir-5189-5p ; hsa-mir-612 ; hsa-mir-661 ; hsa-mir-6827-3p ; hsa-mir-6849-3p ; hsa-mir-6860 ; hsa-mir-766-3p ; hsa-mir-939-3p

Nearest miRNA

hsa-let-7g/Upstream/356623; hsa-mir-12124/Downstream/614427;

Nearest TSS

ENST00000440867/Upstream/15596; ENST00000463408/Downstream/66053;

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/68221, chr3-CpG: 87/Downstream/65990

Upstream sequence

CTTTTAAAATCCTGTGGGACAGACCTCTGCCGCCAGTAGATAGCCTCTGCTACAGATTGTAAAGTGCTACACAAATGTCATGCAACATATTTGAAAACTC

Downstream sequence

TAAAGTTTTAAAAACTTTAGTTATTTAAAAGTGTTATTTAAAAGTCTGATTAGTTTTTACACTTGAGGCTCTGAACATACTTTTCTTTAAGGCAATGACC

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.