Basic Information
VIS ID
TVIS44000779
Fusion event
HTLV-1-ABCC5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q27.1
Reference genome
GRCh37/hg19
Start
183641227/183923439 (Hg38)
End
183641227/183923439 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA3C
Target gene
ABCC5
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-1229-3p ; hsa-mir-935 ; hsa-mir-423-5p ; hsa-mir-188-5p ; hsa-mir-129-5p ; hsa-mir-4308 ; hsa-mir-4254 ; hsa-mir-6510-5p ; hsa-mir-1304-5p ; hsa-mir-1273h-3p ; hsa-mir-6734-5p ; hsa-mir-1226-5p ; hsa-mir-6834-5p ; hsa-mir-3175 ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-4771 ; hsa-mir-3166 ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-3184-5p ; hsa-mir-873-3p ; hsa-mir-499b-5p ; hsa-mir-6763-5p ; hsa-mir-3150a-3p ; hsa-mir-491-5p ; hsa-mir-6848-5p ; hsa-mir-6846-5p ; hsa-mir-185-3p ; hsa-mir-6825-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-4741 ; hsa-mir-4675 ; hsa-mir-1199-3p ; hsa-mir-2467-3p ; hsa-mir-6820-5p ; hsa-mir-6087 ; hsa-mir-6805-5p ; hsa-mir-4758-3p ; hsa-mir-766-3p ; hsa-mir-610 ; hsa-mir-1224-3p ; hsa-mir-3622b-3p ; hsa-mir-3622a-3p ; hsa-mir-4323 ; hsa-mir-634
Nearest miRNA
hsa-let-7g/Upstream/36554; hsa-mir-1224/Downstream/317966;
Nearest TSS
ENST00000440867/Upstream/38506; ENST00000422946/Downstream/19341;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/38353, chr3-CpG: 86/Downstream/93913
Upstream sequence
CAgctgggcacagtagcttgtgcctgtaatcccagcactttgggaggctgaggtgggcggattatctgaggtcagaagttcgagaccagcctggccaaca
Downstream sequence
tggtgaaaccctgtgtctactaaaaatacaaaaattagccaggcatggtggcacatgcctgtactcccagctgctcaggagactgaggcaggagaatcgc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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