Basic Information
VIS ID
TVIS44000798
Fusion event
HTLV-1-ZNF181 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.11
Reference genome
GRCh37/hg19
Start
35226062/34735157 (Hg38)
End
35226062/34735157 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
ZNF181
miRNAs that regulate target gene
hsa-let-7a-3p ; hsa-let-7b-3p ; hsa-let-7f-1-3p ; hsa-mir-98-3p ; hsa-mir-580-5p ; hsa-mir-3662 ; hsa-mir-4698 ; hsa-mir-8070 ; hsa-mir-758-3p ; hsa-mir-3689f ; hsa-mir-3689e ; hsa-mir-3689b-5p ; hsa-mir-3689a-5p ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300
Nearest miRNA
hsa-mir-10395/Upstream/14335803; hsa-let-7e/Downstream/387543;
Nearest TSS
ENST00000633603/Upstream/208; ENST00000600348/Downstream/38043;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/746, chr19-CpG: 60/Downstream/37586
Upstream sequence
TGTCCGCAAATCTTCCTGAAACACTTTATCAGGACTGTGTGTTTGCTTTGCTTCTCCTGCCTGTTCCCACCTAACCAAGTCCATTTAAGGGACTGGATCC
Downstream sequence
ATGGTTCCTTTCAGTATAGGAAGGACGGAGCCCACAGGAGAGCTCCAAGGTATTATCCTCCTCACCCAGTGTTCCTCTTTTCTACAGTTTTCTGCTAGAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate