Basic Information
VIS ID
TVIS44000800
Fusion event
HTLV-1-LPIN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
11855314/11715188 (Hg38)
End
11855314/11715188 (Hg38)
Orient
-
Location type
Intronic
Target gene
LPIN1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-92a-3p ; hsa-mir-17-5p ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-485-5p ; hsa-mir-432-3p ; hsa-mir-122-5p ; hsa-mir-1289 ; hsa-mir-129-5p ; hsa-mir-3198 ; hsa-mir-4294 ; hsa-mir-4309 ; hsa-mir-4802-3p ; hsa-mir-489-3p ; hsa-mir-514a-3p ; hsa-mir-514b-3p ; hsa-mir-6514-5p
Nearest miRNA
hsa-mir-4261/Upstream/174511; hsa-mir-10b/Downstream/52256;
Nearest TSS
ENST00000437798/Upstream/37593; ENST00000464517/Downstream/9034;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/44881, chr2-CpG: 85/Downstream/30935
Upstream sequence
GGAGAGAAGCTCCGCTCTGTGAGAAGGTGCAGGAAATTGAAGTAAGTGACCCCCTTCACCTGTGGGTGGGAGCGCAGGCCACATAGTCATGGAGGCGGCC
Downstream sequence
TCGGGCAGCTTCCCGTGGTTCAGTCCCATTCTCCAGACTGTGGGGCAGGAGCCCATGGCTACCATGTTTCCACCCCAGCTTCTGGCCCCACGTGCAGGAC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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