Basic Information
VIS ID
TVIS44000814
Fusion event
HTLV-1-GSDME integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p15.3
Reference genome
GRCh37/hg19
Start
24765914/24726295 (Hg38)
End
24765914/24726295 (Hg38)
Orient
-
Location type
Intronic
Target gene
GSDME
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-1183/Upstream/3255149; hsa-mir-10399/Downstream/1223624;
Nearest TSS
ENST00000635602/Upstream/1511; ENST00000607375/Downstream/18439;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/152012, chr7-CpG: 106/Downstream/30627
Nearest cancer related gene
GSDME(TSG, No orient, 0)
Upstream sequence
TTTCCATTTTCTCTGCTTCTAAGACTTTCAAGAGCCAAAATGCAAACTCACAGAGGAGAAACCCAGAGACAACTTTTAAAAGTCTGACAATATCCAAAAG
Downstream sequence
GAGGGAAGCAGGTTTCTTTACCAAAGCATAAAGGAGGTCCCGGGGATGCCTCCTGCAGAGACACAGGAGGGCGAGCTTTGTCATGCAGACCCCACACTTC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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