Basic Information
VIS ID
TVIS44000817
Fusion event
HTLV-1-FBXO42 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.13
Reference genome
GRCh37/hg19
Start
16589223/16262728 (Hg38)
End
16589223/16262728 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
FBXO42
miRNAs that regulate target gene
hsa-mir-186-5p ; hsa-mir-1281 ; hsa-mir-6881-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-627-3p ; hsa-mir-877-3p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p
Nearest miRNA
hsa-mir-12136/Upstream/3683705; hsa-mir-101-1/Downstream/596221;
Nearest TSS
ENST00000473358/Upstream/9135; ENST00000475078/Downstream/52639;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/25424, chr1-CpG: 52/Downstream/89351
Upstream sequence
gcagtgagcccagaccgtgcACCAGTACACATGGGGTGGTCAGAGATTACGCGGATCCATCAATTTTGGCAAtttctttttctttttgagacagggtctc
Downstream sequence
actccggttgcccaggctagagtctggagtgcagtggcgtaatcgatctcagctcactgcaactccgacttctcaagctcaggtgattctcacacctcag
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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