Basic Information
VIS ID
TVIS44000826
Fusion event
HTLV-1-PLEKHH1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
68050180/67583463 (Hg38)
End
68050180/67583463 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA14B
Target gene
PLEKHH1
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6514-3p ; hsa-mir-7977 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-3926 ; hsa-mir-6847-3p ; hsa-mir-6811-3p ; hsa-mir-214-5p ; hsa-mir-383-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-4796-3p
Nearest miRNA
hsa-mir-208a/Upstream/141533; hsa-mir-1185-1/Downstream/4933357;
Nearest TSS
ENST00000550708/Upstream/1877; ENST00000559766/Downstream/648;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/11167, chr14-CpG: 61/Downstream/16404
Upstream sequence
cacatttggaacactctgctgtactCTAGGATCTGTAGCATCTTCAATTCTATAGCCCATATTTTTggactggaagccagaatttccacattgttttccc
Downstream sequence
ttgtcggctaccaattaactgtgtctttggaaaaggcacttcacctcagctgcaaaatcaaagttggtcggtgatctctaatattcGAGGGCCCTAAGTT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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