Basic Information
VIS ID
TVIS44000835
Fusion event
HTLV-1-RIN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
19869428/19888784 (Hg38)
End
19869428/19888784 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA20A
Target gene
RIN2
miRNAs that regulate target gene
hsa-mir-429 ; hsa-mir-200a-3p ; hsa-mir-200c-3p ; hsa-mir-141-3p ; hsa-mir-200b-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/1418093; hsa-mir-1-1/Downstream/6319402;
Nearest TSS
ENST00000382410/Upstream/2263; ENST00000465815/Downstream/591;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/129655, chr20-CpG: 37/Downstream/86108
Upstream sequence
ATACTTGATCCTGGGACAGTCACTGGGTAAGGAAGGGTTTGGGGTTGCTCCCCCAGGCCCCCCTCAATGCGTGAAGGCCTGAGCCAGGTCAGCTGGCAGA
Downstream sequence
GGTGTGTGTATGTTTAACTTAGAACTGAATGTTGAAGGCTTTGTGACCCAAAGGGAAGAATTATTGGGATCTGATGCCCTAGCAGGGGAAATTCCAAGCC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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