Basic Information
VIS ID
TVIS44000862
Fusion event
HTLV-1-IQCE integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
2609175/2569541 (Hg38)
End
2609175/2569541 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7B
Target gene
IQCE
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-124-3p ; hsa-mir-221-3p ; hsa-mir-3678-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-513b-5p ; hsa-mir-2467-3p ; hsa-mir-7110-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-125b-2-3p ; hsa-mir-4457 ; hsa-mir-3153 ; hsa-mir-451b ; hsa-mir-4681 ; hsa-mir-6733-5p ; hsa-mir-6739-5p
Nearest miRNA
hsa-mir-339/Upstream/42396; hsa-mir-10399/Downstream/2219024;
Nearest TSS
ENST00000635602/Upstream/2982; ENST00000497572/Downstream/10569;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/9972, chr7-CpG: 16/Downstream/22996
Upstream sequence
CCCTTTGGATCATCCTGGGCTTGTTTTGCTGCCAGGGTTCTATTCTTCCTCACCCTCAGCAGGAGGAGGGCAGCATTTGCCACCCTGCTTGTCCAGGAGG
Downstream sequence
GTGCCGCGGAGGTGGGGTTAGTCCAGGTGGCCCCGAGGCCCCTCTGTCTCTAATGCCGCTCTCGTGTACAGCAGCCCGTGTGCCGACCTTGTGCGTACGA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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