Basic Information
VIS ID
TVIS44000877
Fusion event
HTLV-1-FRMD5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q15.3
Reference genome
GRCh37/hg19
Start
44415894/44123696 (Hg38)
End
44415894/44123696 (Hg38)
Orient
+
Location type
Intronic
Target gene
FRMD5
miRNAs that regulate target gene
hsa-mir-5582-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-6822-3p ; hsa-mir-6502-5p ; hsa-mir-1301-5p ; hsa-mir-517-5p ; hsa-mir-645 ; hsa-mir-4305 ; hsa-mir-499b-5p ; hsa-mir-3936
Nearest miRNA
hsa-mir-1233-1/Upstream/329937; hsa-mir-10393/Downstream/594148;
Nearest TSS
ENST00000557528/Upstream/199382; ENST00000429162/Downstream/70750;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/296617, chr15-CpG: 105/Downstream/70847
Upstream sequence
AACCAGAAAATCAACTTTTATAAAAAGCAACACAACACATTGAGAAAACTGACAAAAGTTTCTTGTCCAAAAATGTAAAAGAAAACAAACATGCAATTAC
Downstream sequence
ATAAGGGCGACACCTAAAATTCACTCATAAGTGGTCaaagagagaaaaagataaattttgaaaaagaaaatacaaatgggaatcatctgagaaaatacaa
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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