Basic Information
VIS ID
TVIS44000880
Fusion event
HTLV-1-SMAP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p34.2
Reference genome
GRCh37/hg19
Start
40853588/40387916 (Hg38)
End
40853588/40387916 (Hg38)
Orient
-
Location type
Intronic
Target gene
SMAP2
miRNAs that regulate target gene
hsa-mir-708-5p ; hsa-mir-652-3p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-25-3p ; hsa-let-7e-5p
Nearest miRNA
hsa-mir-12136/Upstream/2298587; hsa-mir-101-1/Downstream/366439;
Nearest TSS
ENST00000473358/Upstream/13268; ENST00000487871/Downstream/5429;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/13566, chr1-CpG: 53/Downstream/62017
Upstream sequence
cggagctggctccctcggcttgcggggaggtgtggagggagccagctccgggaaccggggctgtgtgccgcacttgtgggccagctggagttccgggtgg
Downstream sequence
gcatgggcttggcgggccccgcacttggagcagccggccagccctgctggccctgggcaatgaggggcttagcacctgggccagcggctgcagagggtgt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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