Basic Information
VIS ID
TVIS44000886
Fusion event
HTLV-1-ABCA1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
107650533/104888252 (Hg38)
End
107650533/104888252 (Hg38)
Orient
-
Location type
Intronic
Target gene
ABCA1
miRNAs that regulate target gene
hsa-mir-33b-5p ; hsa-mir-33a-5p ; hsa-mir-26a-5p ; hsa-mir-26b-5p ; hsa-mir-19a-3p ; hsa-mir-27a-3p ; hsa-mir-128-3p ; hsa-mir-27b-3p ; hsa-mir-613 ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-17-5p ; hsa-mir-20b-5p ; hsa-mir-33a-3p ; hsa-mir-33b-3p ; hsa-mir-148a-5p ; hsa-mir-302a-3p
Nearest miRNA
hsa-let-7a-1/Upstream/6659035; hsa-mir-12126/Downstream/1712676;
Nearest TSS
ENST00000422679/Upstream/57263; ENST00000435915/Downstream/39301;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/123754, chr9-CpG: 23/Downstream/38236
Upstream sequence
TGTGAGAAAGATGGGACCAGGCCAAGAAACACAATTAAAAGGTGGCCCTGGCCCCACTGCTTTCCTGGAAGAACAGTATCTCATAAGCTTGTGGGTCTCG
Downstream sequence
TAGGGGTATGGACTGAGCTGCTTAGTGGTAGGAAAAATCACTAGGGCAGTGAAACTGAAGTCCCAGCTACATTTCCCAGCTACGTAAATGTTGATCCTTT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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