Basic Information
VIS ID
TVIS44000894
Fusion event
HTLV-1-NBPF8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
148184404/145224062 (Hg38)
End
148184404/145224062 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
NBPF8
miRNAs that regulate target gene
hsa-mir-421 ; hsa-mir-505-3p ; hsa-mir-4716-5p ; hsa-mir-4709-5p ; hsa-mir-1273h-3p ; hsa-mir-4771 ; hsa-mir-3166 ; hsa-mir-499b-5p
Nearest miRNA
hsa-mir-101-1/Upstream/28129334; hsa-mir-1182/Downstream/626525;
Nearest TSS
ENST00000473358/Upstream/128062; ENST00000618589/Downstream/18062;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/7841, chr1-CpG: 37/Downstream/8772
Upstream sequence
ATAGTAACATTTGTAggccgggcacggtggctcacacctgtaatcccaacactttgggaggccgaggcttgcggatcatgaggtcaggagatcgagacca
Downstream sequence
tcctggctaacacggtgaaactctgtctctactaaaatacaaaaaaattagccgggcgtggtggcgggcacctgtagtcccagctacttgggaggctgag
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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