Basic Information
VIS ID
TVIS44000898
Fusion event
HTLV-1-KDM2B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
121976552/121538647 (Hg38)
End
121976552/121538647 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
KDM2B
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-324-3p ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-4772-3p ; hsa-mir-3605-3p ; hsa-mir-6787-3p ; hsa-mir-1304-3p ; hsa-mir-6774-3p ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-6736-3p ; hsa-mir-6890-3p ; hsa-mir-216a-5p ; hsa-mir-6722-5p ; hsa-mir-652-3p ; hsa-mir-5197-5p ; hsa-mir-146a-5p ; hsa-mir-448
Nearest miRNA
hsa-let-7i/Upstream/94295; hsa-mir-3612/Downstream/1157260;
Nearest TSS
ENST00000382841/Upstream/1031; ENST00000541574/Downstream/10992;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/412, chr12-CpG: 169/Downstream/39618
Upstream sequence
CCTGGTGGCTTAGTGACTGTGTACCCTACATCATAGCATGGTTGAGAGACTCCTTTGAGATAAATACATATTCACCgcatcatccaaactgtggtacctg
Downstream sequence
gattacttaatccaaacttcacaacaaccctaaaaagtcattcccaggattcttcctgttttcagataagcacagggaggcTTGTGACTCAAGCCTCGAG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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