Basic Information
VIS ID
TVIS44000909
Fusion event
HTLV-1-UNC13B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
35227871/35227874 (Hg38)
End
35227871/35227874 (Hg38)
Orient
-
Location type
Intronic
Target gene
UNC13B
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-221-3p ; hsa-mir-92a-3p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-101-2/Upstream/1759939; hsa-let-7a-1/Downstream/380220;
Nearest TSS
ENST00000422679/Upstream/76; ENST00000481299/Downstream/113956;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/65462, chr9-CpG: 89/Downstream/261833
Upstream sequence
TGttgtcaggagcctggaacagagatttttgcattggatatgagatcagattgacttttaaggtctcgtctgactctTTGCCTTTCAAGTTTTGATCAGA
Downstream sequence
AGTCTCAGCTTTTTTTCTCCAGGTTTAGATTTAACAATCTAAACCTAGTTCTAACATTGGTATGTAGTGCCTAATAAATGTTGCTTAAGTAAAATGAACT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate