VISDB - VIS Detail

Basic Information

VIS ID

TVIS44000916

Fusion event

HTLV-1-IPO9 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr1

Cytoband

q32.1

Reference genome

GRCh37/hg19

Start

201846274/201877146 (Hg38)

End

201846274/201877146 (Hg38)

Orient

Location type

UTR3

Target gene

IPO9

miRNAs that regulate target gene

hsa-mir-1-3p ; hsa-mir-339-5p ; hsa-mir-30c-5p ; hsa-mir-619-5p ; hsa-mir-4662a-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-6504-3p ; hsa-mir-3159 ; hsa-mir-449b-3p ; hsa-mir-4438 ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-5687 ; hsa-mir-6070 ; hsa-mir-6793-3p ; hsa-mir-4301 ; hsa-mir-5096 ; hsa-mir-1303 ; hsa-mir-197-3p ; hsa-mir-6832-5p ; hsa-mir-193b-5p ; hsa-mir-5580-5p ; hsa-mir-3190-5p ; hsa-mir-411-5p ; hsa-mir-483-5p ; hsa-mir-4776-3p ; hsa-mir-4659b-5p ; hsa-mir-4659a-5p ; hsa-mir-5590-5p ; hsa-mir-6888-3p ; hsa-mir-3120-5p ; hsa-mir-6895-3p ; hsa-mir-4638-3p ; hsa-mir-6845-3p ; hsa-mir-3117-5p ; hsa-mir-6777-3p ; hsa-mir-3654 ; hsa-mir-6757-3p ; hsa-mir-4435 ; hsa-mir-6762-3p ; hsa-mir-4755-3p ; hsa-mir-6883-3p ; hsa-mir-331-5p ; hsa-mir-642b-5p ; hsa-mir-1294 ; hsa-mir-4316 ; hsa-mir-202-3p ; hsa-mir-4677-3p ; hsa-mir-454-5p ; hsa-mir-4678 ; hsa-mir-606 ; hsa-mir-98-5p ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7b-5p ; hsa-mir-4458 ; hsa-let-7a-5p ; hsa-let-7f-5p ; hsa-let-7c-5p ; hsa-let-7d-5p ; hsa-let-7e-5p ; hsa-mir-4500

Nearest miRNA

hsa-mir-101-1/Upstream/13699; hsa-mir-1182/Downstream/125978;

Nearest TSS

ENST00000473358/Upstream/2831; ENST00000481699/Downstream/11534;

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/47576, chr1-CpG: 41/Downstream/11640

Upstream sequence

TTAGGTGGAGCCTGTCTAAACATTCTAGTGTGTCTTGGCAAACATAGCCTGAAATGATTCTTAAAGAACTGGCATTGTTTAATCAAATATTTTTAAGGGA

Downstream sequence

GATTCCTTAATTGGGAAGTTTAGTCTGTTTGGGGTTCAAAGAGTAAATGAGGATTAGAAAATCATGGAGAGAggctgggcgcggtggctaacgcctgtaa

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.