Basic Information
VIS ID
TVIS44000955
Fusion event
HTLV-1-RRP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
45219561/43799680 (Hg38)
End
45219561/43799680 (Hg38)
Orient
-
Location type
Intronic
Target gene
RRP1
miRNAs that regulate target gene
hsa-mir-615-3p ; hsa-mir-92b-3p ; hsa-mir-423-3p ; hsa-mir-149-5p
Nearest miRNA
hsa-let-7c/Upstream/189691; hsa-mir-6815/Downstream/1678586;
Nearest TSS
ENST00000624081/Upstream/2319; ENST00000474735/Downstream/10651;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/9681, chr21-CpG: 19/Downstream/3901
Upstream sequence
AGGGCTGAACCTGAGGCTGGTGAGGAGCAGGCAGGTGACGACAGGGACAGTGGCGGCCCCGTTCTCCAGGTGGGTTCCCTGGGCTCATGGCTGTGCCCTC
Downstream sequence
AGCCTTTGCCCCTCTGTGCTACCGCTTGCTCTGGAAGAGGAGGGGGGCGTTAGGAGGGAGGATGGCAGCTGTTGGCATGGAGAGTTACCCGGACAGGGGT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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