Basic Information
VIS ID
TVIS44000960
Fusion event
HTLV-1-ARAP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p14
Reference genome
GRCh37/hg19
Start
36179402/36177780 (Hg38)
End
36179402/36177780 (Hg38)
Orient
-
Location type
Intronic
Target gene
ARAP2
miRNAs that regulate target gene
hsa-mir-101-3p ; hsa-mir-26b-5p ; hsa-mir-106b-5p ; hsa-mir-20a-5p ; hsa-mir-4703-5p ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-6071 ; hsa-mir-6828-3p ; hsa-mir-3144-3p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-582-5p ; hsa-mir-6847-3p ; hsa-mir-5186 ; hsa-mir-767-3p ; hsa-mir-4666a-3p ; hsa-mir-1255b-2-3p ; hsa-mir-338-5p ; hsa-mir-300 ; hsa-mir-381-3p ; hsa-mir-144-3p ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-623 ; hsa-mir-3682-5p ; hsa-mir-6883-3p ; hsa-mir-4699-3p ; hsa-mir-627-3p ; hsa-mir-204-5p ; hsa-mir-211-5p ; hsa-mir-1305 ; hsa-mir-335-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-12113/Upstream/7358112; hsa-mir-1243/Downstream/248586;
Nearest TSS
ENST00000502981/Upstream/16280; ENST00000502245/Downstream/32965;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/5454560, chr4-CpG: 100/Downstream/66229
Upstream sequence
ATCACTATTTCTTTGGTATATTTAGTGGAGTACACAATGCTAAAACAAGACTCTATAAGTAAAATCACTAATAATCCTTCCAAACAAAACATAGTTGTTA
Downstream sequence
CTATAATAAAATAGCAGCAATTTGCAATGACTATAACAGAGCTCACCTGTTCGTTTTTGCAAAGCCACACACTGTTTCCACTTAACACAGTAAAAATTTT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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