Basic Information
VIS ID
TVIS44000962
Fusion event
HTLV-1-ITK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
156607995/157180984 (Hg38)
End
156607995/157180984 (Hg38)
Orient
-
Location type
Exonic
Target gene
ITK
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-6083 ; hsa-mir-7111-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-5196-3p ; hsa-mir-3183 ; hsa-mir-3074-3p ; hsa-mir-3591-3p ; hsa-mir-21-3p
Nearest miRNA
hsa-mir-10397/Upstream/2351444; hsa-mir-103a-1/Downstream/3293418;
Nearest TSS
ENST00000502646/Upstream/117; ENST00000519759/Downstream/41765;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/37928, chr5-CpG: 91/Downstream/84818
Nearest cancer related gene
ITK(OG, No orient, 0)
Upstream sequence
TGCCTCCACATTGCATTCTTTGCCCCAAAACTCTTTCCTTTGGTTGTGCTAAGAGGTGATGCCCAAGGTGCACCACCTTTCAAGAACTGGATCATGAACA
Downstream sequence
ACTTTATCCTCCTGGAAGAACAGCTCATCAAGAAATCCCAACAAAAGAGAAGAACTTCTCCCTCGAACTTTAAAGTCCGCTTCTTTGTGTTAACCAAAGC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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