Basic Information
VIS ID
TVIS44000970
Fusion event
HTLV-1-CDC20 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p34.2
Reference genome
GRCh37/hg19
Start
43828640/43362969 (Hg38)
End
43828640/43362969 (Hg38)
Orient
+
Location type
Exonic
Target gene
CDC20
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-215-5p ; hsa-mir-34a-5p ; hsa-mir-192-5p ; hsa-mir-30a-5p ; hsa-mir-16-5p ; hsa-mir-941 ; hsa-mir-93-3p ; hsa-mir-188-5p ; hsa-mir-23b-3p ; hsa-mir-92a-3p ; hsa-mir-18a-5p
Nearest miRNA
hsa-mir-12136/Upstream/191257; hsa-mir-101-1/Downstream/1679;
Nearest TSS
ENST00000473358/Upstream/1911; ENST00000436713/Downstream/2245;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/3581, chr1-CpG: 27/Downstream/4174
Upstream sequence
aaaGGTAGGTGGGTGGCCCAGTGCCTCCTTTATGGCTATGGCTGCATCAGCATTCGTATGTACTGTTCTCATTTGCTCCAGGTCACACATCCCGGGTCCT
Downstream sequence
GAGTCTGACCATGAGCCCAGATGGGGCCACAGTGGCATCCGCAGCAGCAGATGAGACCCTGAGGCTATGGCGCTGTTTTGAGTTGGACCCTGCGCGGCGG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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