Basic Information
VIS ID
TVIS44000980
Fusion event
HTLV-1-MALL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q13
Reference genome
GRCh37/hg19
Start
110859631/110102054 (Hg38)
End
110859631/110102054 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
MALL
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-7977 ; hsa-mir-3178 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-6499-5p ; hsa-mir-4650-5p ; hsa-mir-1972 ; hsa-mir-383-3p ; hsa-mir-3123 ; hsa-mir-1238-5p ; hsa-mir-1270 ; hsa-mir-17-3p ; hsa-mir-25-5p ; hsa-mir-3174 ; hsa-mir-4481 ; hsa-mir-4683 ; hsa-mir-4745-5p ; hsa-mir-4758-5p ; hsa-mir-596 ; hsa-mir-6087 ; hsa-mir-620 ; hsa-mir-6499-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/15531; hsa-mir-10b/Downstream/182799;
Nearest TSS
ENST00000437798/Upstream/113782; ENST00000456683/Downstream/13767;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/29828, chr2-CpG: 54/Downstream/13314
Upstream sequence
CTGCTCCCACCGCGGCCCGGTGGCTGGGCTTCCCCACTCTCCCTGGCCCCCTGCCCCAGTGTCCTCTTTCTCACTCTCCCTGTACATTGATTAACTTCAT
Downstream sequence
GTTCCTGCCCATGTTCCCCAAAAGAAGTTGCCTGATGATCCCTGGACTCAGGCTCAGGGGAAGTCCCCATACCCTCCTTTCTCCTCAGGAGCCCACAGAC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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