Basic Information
VIS ID
TVIS44000985
Fusion event
HTLV-1-EPB41L4A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
111648930/112313233 (Hg38)
End
111648930/112313233 (Hg38)
Orient
+
Location type
Intronic
Target gene
EPB41L4A
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10397/Upstream/1799318; hsa-mir-103a-1/Downstream/3942510;
Nearest TSS
ENST00000502646/Upstream/5831; ENST00000624967/Downstream/79551;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/151890, chr5-CpG: 194/Downstream/105547
Upstream sequence
AATTCCAGAATATAATGCAAAGTGATGTGATGCGGGAAGTCTTTGACCAGCCTATTAGAATCCCTGAGAAGCCCTAGGGCTATGAAGCGACTAAGAAACT
Downstream sequence
TCTAAAAAGTGACTAAAAACTTTATTGAGAAAGTGAGACAGGGAGAGATTTGGTTATCATCAAAAGTCCTTTTGTAGGGTgggcgcggtggctcacgcct
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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