Basic Information
VIS ID
TVIS44000990
Fusion event
HTLV-1-AFAP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
7921736/7920009 (Hg38)
End
7921736/7920009 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4A
Target gene
AFAP1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-3613-5p ; hsa-mir-2115-5p ; hsa-mir-646 ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-942-3p ; hsa-mir-5582-3p ; hsa-mir-4802-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-578
Nearest miRNA
hsa-mir-378d-1/Upstream/459891; hsa-mir-12113/Downstream/85292;
Nearest TSS
ENST00000502981/Upstream/47696; ENST00000623059/Downstream/18992;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/119296, chr4-CpG: 156/Downstream/18827
Upstream sequence
tctgccttagtttgctgaggataatggcttccagctccatccatgtccctgcaaaggacatgatcttgttccttttgatgggtgaatagtattccatggt
Downstream sequence
gtgtatgtaccacattttctttagtctatcattgatgggcgtttgggttgattccctgtctttgctactgtgaacagtgctgcaatgaacatacgcgtac
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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