Basic Information
VIS ID
TVIS44001015
Fusion event
HTLV-1-CCDC91 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p11.22
Reference genome
GRCh37/hg19
Start
28697198/28544265 (Hg38)
End
28697198/28544265 (Hg38)
Orient
-
Location type
Intronic
Target gene
CCDC91
miRNAs that regulate target gene
hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-5689
Nearest miRNA
hsa-mir-1244-3/Upstream/2670186; hsa-let-7i/Downstream/13779435;
Nearest TSS
ENST00000382841/Upstream/91723; ENST00000542814/Downstream/4798;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/353291, chr12-CpG: 91/Downstream/604777
Upstream sequence
catctacttctctgatctcctcccctaccagtctcctccttggtaattttgctccaatcttaatggatttcttaccagttctccatcaaaccaagtctgc
Downstream sequence
accccccttttggagttttttccttgtgtttccagctaccttgagaatttctttccccatgtttttagatagctcccttcttgtctcttttcaagtctct
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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