Basic Information
VIS ID
TVIS44001019
Fusion event
HTLV-1-MARCH3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
126297046/126961354 (Hg38)
End
126297046/126961354 (Hg38)
Orient
-
Location type
Intronic
Target gene
MARCH3
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-744-5p ; hsa-mir-4455 ; hsa-mir-574-5p ; hsa-mir-190a-3p ; hsa-mir-889-3p ; hsa-mir-6867-5p ; hsa-mir-5011-5p ; hsa-mir-511-3p ; hsa-mir-1277-5p ; hsa-mir-4776-3p ; hsa-mir-4715-3p ; hsa-mir-3064-3p ; hsa-mir-3119 ; hsa-mir-129-5p ; hsa-mir-4438 ; hsa-mir-510-3p ; hsa-mir-203a-3p
Nearest miRNA
hsa-mir-10397/Upstream/7806638; hsa-mir-103a-1/Downstream/2136334;
Nearest TSS
ENST00000502646/Upstream/43126; ENST00000515002/Downstream/68815;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/182817, chr5-CpG: 174/Downstream/68577
Upstream sequence
TTGAAAAGGTTTCAACACATTCTCTTTGTCAAAAATGAGGAACATTGATCTACATGAAGGATTTGCATAGAGGTTATCAAAATAAAATTTCAGAGAATCG
Downstream sequence
TGAGAGGGCAGAATTTGGGGTGTTCAATCCCCAATCAGAGATGTCCAAACTCAGACATCTGTCTTTCAGAAGCAACCACCATAAGGCTGATGAAAAGGGC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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