Basic Information
VIS ID
TVIS44001061
Fusion event
HTLV-1-SORCS3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
106449223/104689465 (Hg38)
End
106449223/104689465 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
SORCS3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-107/Upstream/421060; hsa-mir-202/Downstream/6208625;
Nearest TSS
ENST00000439456/Upstream/23265; ENST00000393176/Downstream/469463;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/46411, chr10-CpG: 100/Downstream/2474557
Upstream sequence
gcccatgttgccatccacattccacaatgtgtggacttgtggttgtttgtttgcgtgtctgtctcttcatgtagactggaagttccatgaATTATATCTT
Downstream sequence
TTAAtcattcatgcctcagggcctttgcacaagctgttggttctacttgggacactttcatcttctcactgttcatgagatctcagcttaaatgtcacct
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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