Basic Information
VIS ID
TVIS44001065
Fusion event
HTLV-1-GEMIN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
39589110/39119906 (Hg38)
End
39589110/39119906 (Hg38)
Orient
+
Location type
Intronic
Target gene
GEMIN2
miRNAs that regulate target gene
hsa-mir-200c-3p ; hsa-mir-200a-3p ; hsa-mir-25-3p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-92b-3p ; hsa-mir-576-3p ; hsa-mir-4426 ; hsa-mir-4427 ; hsa-mir-4647 ; hsa-mir-4662b ; hsa-mir-219b-3p ; hsa-mir-4680-3p ; hsa-mir-5187-3p ; hsa-mir-219a-2-3p
Nearest miRNA
hsa-mir-208a/Upstream/2167515; hsa-mir-1185-1/Downstream/8641089;
Nearest TSS
ENST00000550708/Upstream/5575; ENST00000529365/Downstream/11867;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/5409, chr14-CpG: 23/Downstream/50254
Upstream sequence
TTGCCAATGGTCATTTAACTTGTAAAAGGTATAGCTAGTCCTTCTATCAAAGAAGCATGCGCACATAAACACACAAAAGGTATGCTTAAGGTTCAAACCC
Downstream sequence
AAGTTGGTCTGTCTCTAAAGCCTGTGTGCCTTTGACTATGCAATGGTGCCTTCCTAGTACCAAGGATGTATGTATGTAGTAGGGACAGGGCTAGGTAGGT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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